HIV Treatments: Reverse Transcriptase (RT) Inhibitors

Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs)

peterstaley — Thu, 02 Oct 2008 16:13:20 -0400

What are they? A list of approved and experimental NRTIs.

Link: http://www.aidsmeds.com/archive/NRTIs_1082.shtml

Human immunodeficiency virus 1

mjones419 — Mon, 22 Sep 2008 12:12:33 -0400

Human immunodeficiency virus 1 (HIV-1)-specific reverse transcriptase (RT) inhibitors may suppress the replication of specific drug-resistant (E138K)RT HIV-1 mutants or select for highly resistant (Y181C-->C181I)RT HIV-1 mutants.

Link: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=44...

Quinoxalinylethylpyridylthioureas (QXPTs) as Potent Non-Nucleoside

mjones419 — Mon, 22 Sep 2008 12:10:48 -0400

Quinoxalinylethylpyridylthioureas (QXPTs) as Potent Non-Nucleoside HIV-1 Reverse Transcriptase (RT) Inhibitors. Further SAR Studies and Identification of a Novel Orally Bioavailable Hydrazine-Based Antiviral Agent

Link: http://pubs.acs.org/cgi-bin/abstract.cgi/jmcmar/2001/44/i03/...

The Phenylmethylthiazolylthiourea Nonnucleoside Reverse Transcriptase (RT) Inhibitor MSK-076 Selects

mjones419 — Mon, 22 Sep 2008 12:02:34 -0400

Medical Journal Article on The Phenylmethylthiazolylthiourea Nonnucleoside Reverse Transcriptase (RT) Inhibitor MSK-076 Selects for a Resistance Mutation in the Active Site of Human Immunodeficiency Virus Type 2 RT

Link: http://jvi.asm.org/cgi/content/full/78/14/7427

HIV-1 Reverse Transcriptase

mjones419 — Mon, 22 Sep 2008 12:00:27 -0400

HIV-1 Reverse Transcriptase

Link: http://www.callutheran.edu/Academic_Programs/Departments/Bio...